| Darla Moore and Richard Rainwater Foundation | $55.5M | 52 | $37.5K |
| BlueCross BlueShield of South Carolina Foundation | $42.7M | 121 | $250K |
| Medtronic Communities Foundation | $29.2M | 29 | $250K |
| Hca Healthcare Foundation | $25.4M | 999 | $5K |
| The David and June Trone Family Foundation | $12.7M | 53 | $25K |
| Danaher Foundation | $12.1M | 43 | $50K |
| The Eleanor and J Hunter Flack Foundation Inc | $11.1M | 8 | $577.5K |
| Richard L Duchossois Foundation | $10.9M | 8 | $100K |
| The Williams Brice Edwards Charitable Trust | $10.1M | 69 | $45K |
| Elhapa Foundation Inc | $9.7M | 249 | $25K |
| Beemok Family Foundation | $9.7M | 39 | $25K |
| Drs Bruce & Lee Foundation | $8.4M | 20 | $74K |
| Darnall W and Susan F Boyd Foundation Inc | $6.8M | 17 | $150K |
| The Jolley Foundation | $6.6M | 174 | $30K |
| Lb Foundation | $6.5M | 40 | $85.4K |
| Cw and Dorothy G Love Foundation | $5.8M | 132 | $20K |
| Robert S Campbell Foundation | $5.4M | 6 | $209K |
| The Labcorp Charitable Foundation | $5.3M | 560 | $704 |
| Watson-brown Foundation Inc | $5.2M | 153 | $6K |
| Betsy M Campbell Foundation | $5.1M | 6 | $132.7K |
| Guffey Family Foundation | $5M | 51 | $10K |
| Kimberly-Clark Foundation | $4.9M | 14 | $175.5K |
| Canal Charitable Foundation | $4.1M | 13 | $15K |
| Equifax Foundation Inc | $4M | 16 | $87.5K |
| Ch Robinson Worldwide Foundation | $4M | 87 | $5K |
| Abney Foundation | $3.9M | 102 | $15K |
| James Purdy Barrow Foundation | $3.9M | 20 | $25K |
| 1772 Foundation Inc | $3.8M | 87 | $10K |
| The Lancaster County Partners for Youth | $3.3M | 11 | $193.8K |
| Franklin Templeton Charitable Foundation Inc | $3.2M | 98 | $24.9K |
| The Fullerton Foundation | $3.1M | 92 | $24K |
| The Ceres Foundation Inc | $3M | 176 | $10K |
| Yawkey Foundation | $2.9M | 26 | $25K |
| The Edward E Hood Jr Foundation | $2.8M | 50 | $1K |
| The J H Walker Legacy Foundation C/o Sterling Foundation Management LLC | $2.8M | 67 | $50K |
| Genworth Foundation | $2.8M | 23 | $2K |
| The Judith Atkins Wall Foundation | $2.6M | 9 | $173.3K |
| Michael J Mungo Foundation | $2.6M | 45 | $15K |
| Meadows Road Foundation (Fka Coydog Foundation) | $2.6M | 88 | $5K |
| Mary Black Foundation Inc | $2.6M | 43 | $30K |
| The Toby Cassels Foundation | $2.3M | 17 | $150K |
| Milliken & Company Charitable Foundation | $2.2M | 141 | $1K |
| Scsymmes Foundation | $2.1M | 28 | $52.5K |
| The Simpson Foundation | $2.1M | 33 | $20K |
| Nutramax Family Foundation | $2.1M | 64 | $6.8K |
| Gibbs Charitable Foundation | $2M | 52 | $8.8K |
| The Springs Close Foundation Inc | $2M | 101 | $10K |
| The Gleason Family Foundation Inc | $1.9M | 90 | $7K |
| Ka Foundation | $1.9M | 19 | $55K |
| Nagrodsky Family Foundation | $1.9M | 15 | $50K |
| Cassels Family Foundation | $1.8M | 17 | $50K |
| Ralph & Virginia Hendricks Foundati | $1.8M | 50 | $10K |
| Arch Group Foundation | $1.8M | 12 | $10K |
| The John R and M Margrite Davis Foundation | $1.7M | 100 | $9.4K |
| Sargent Foundation 5621-14-48 | $1.7M | 38 | $5K |
| Jim Hudson Foundation | $1.7M | 26 | $30K |
| Jean T and Heyward G Pelham Foundation | $1.6M | 48 | $15K |
| Jerry and Anita Zucker Family Foundation Inc | $1.6M | 8 | $237.5K |
| J M Smith Foundation | $1.6M | 317 | $2.3K |
| Giving Ministry Foundation | $1.6M | 27 | $25K |
| The Jim Parke Foundation C/o Marilyn J Parke | $1.6M | 25 | $25K |
| Daniel-Mickel Foundation | $1.5M | 178 | $2K |
| Dawn Laurel Foundation | $1.5M | 42 | $20K |
| The Chester Foundation | $1.5M | 33 | $15K |
| Chris and Dee Dee Gibson Fndn | $1.5M | 6 | $150K |
| Kauffmann Family Foundation Inc | $1.4M | 68 | $18K |
| Bill and Connie Timmons Foundation | $1.4M | 49 | $17K |
| Freeman Foundation | $1.4M | 47 | $25K |
| nVent Foundation | $1.4M | 58 | $13.8K |
| Helga Marston Foundation | $1.3M | 88 | $2.8K |
| Marlboro County General Hospital | $1.3M | 13 | $103.7K |
| John I Smith Charities Inc | $1.3M | 44 | $25K |
| Delta Foundation | $1.2M | 70 | $3K |
| The Borch Foundation | $1.2M | 39 | $2K |
| Rodney B & Marjorie S Fink Foundation Inc | $1.2M | 35 | $20K |
| First Citizens Foundation Inc Co First | $1.2M | 79 | $10K |
| Burlington Stores Charitable Foundation | $1.2M | 25 | $5K |
| Ingredion Charitable Foundation | $1.2M | 48 | $10K |
| The American Home Foundation | $1.1M | 21 | $43.3K |
| Comporium Foundation Inc | $1.1M | 122 | $3.6K |
| Harvest Charities | $1.1M | 20 | $22.5K |
| Top Family Foundation Inc | $1.1M | 24 | $50K |
| Kilbourne Eh Res Char Tr-main | $1.1M | 57 | $10.5K |
| The Harvey-mcnairy Foundation Inc | $1M | 46 | $5K |
| Davis Family Foundation Inc | $1M | 92 | $2.5K |
| The Deloache Family Foundation | $1M | 36 | $20K |
| Kuznik Charitable Foundation | $1M | 52 | $25K |