Scott R Mackenzie Foundation Inc Grants

The benefactor desires that grantee shall use the gift to continue the project awarded in 2022 to establish a novel treatment strategy for diabetic kidney disease. Previous support from the mackenzie foundation is allowing mdi bio lab to understand the structure and functional parts of the hpa2 molecule and establish a baseline from which to fully understand its function. Based on this ongoing work, mdi bio lab now seeks to investigate the effect of diabetes in a model organism of aging (african turquoise killifish). Simultaneously, mdi bio lab also proposes to use this model to study the loss of peritubular capillaries observed during kidney aging.

This project seeks to continue the project awarded in 2022 to establish a novel treatment strategy for diabetic kidney disease. Previous support from the mackenzie foundation is allowing mdi bio lab to understand the structure and functional parts of the hpa2 molecule and establish a baseline from which to fully understand its function. Based on this ongoing work, mdi bio lab now seeks to investigate the effect of diabetes in a model organism of aging (african turquoise killifish). Simultaneously, mdi bio lab also proposes to use this model to study the loss of peritubular capillaries observed during kidney aging.

The benefactor desires that grantee shall use the gift to optimize and validate a computational pathology-based image risk predictor (ovarisc) that predicts outcome and response in advanced oca receiving primary platinum-based combination chemotherapy, and to confirm the association between ovarisc scores and response to ici on a blinded validation set obtained from an independent clinical trial.

The benefactor desires that grantee shall use the gift to focus on quantifying selective pressures applied by nucleotide depletion and genomic stress in order to dissect the evolutionary dynamics of cancer cells across multiple tumor types, including leukemia, lymphoma, myeloma, colorectal cancer, melanoma, and retinoblastoma.

Year 2 funding - this project seeks to focus on quantifying selective pressures applied by nucleotide depletion and genomic stress in order to dissect the evolutionary dynamics of cancer cells across multiple tumor types, including leukemia, lymphoma, myeloma, colorectal cancer, melanoma, and retinoblastoma.